MOLECULAR PATHWAYS THAT PLAY A ROLE IN THE PREECLAMPSIA PATHOPHYSIOLOGY

Preeclampsia (PE) is an obstetric disease seen in approximately 4-5% of pregnancies progressing with hypertension and urinary proteinuria. It may cause maternal fetal complications. Despite numerous researches the field PE, underlying pathogenesis remains unclear. However, these related studies, it has been concluded that there are many molecular mechanisms trigger PE. Based on mechanisms, PE can be examined two stages. The first stage placental ischemia caused by abnormal placentation. In second stage, necrotic apoptotic factors released from ischemic placenta into circulation systemic inflammation endothelial dysfunction. One cells antiangiogenic factor. Also, imbalance antioxidant prooxidant thought to due recurrent reperfusion injury inflammatory response associated immunological resulting contact immune trophoblasts. aim this review present current implicating pathway leading development new insights conclusion a better understanding relevant will guide further studies.